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MTEP hydrochloride
CAS No. 1186195-60-7
MTEP hydrochloride( 3-((2-Methyl-13-thiazol-4-yl)ethyn-yl)pyridine hydrochloride | MTEP )
Catalog No. M20812 CAS No. 1186195-60-7
MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 178 | In Stock |
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| 50MG | 356 | In Stock |
|
| 100MG | 534 | In Stock |
|
| 200MG | 740 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMTEP hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM respectively).
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DescriptionMTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM respectively).(In Vitro):MTEP shows highly selective for mGluR5 over mGluR1, has no effect on other mGluR subtypes, and has fewer off-target effects than MPEP (HY-14609A).(In Vivo):MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.).MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice.
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In Vitro——
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In VivoAnimal Model:Male Wistar rats (215-315 g, 5-9/group)Dosage:1, 3 and 5 mg/kg Administration:IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)Result:Inhibited the catalepsy induced by Haloperidol (HY-14538).Animal Model:Male C57BL/6J mice (23-25 g)Dosage:0.3, 1 and 3 mg/kg Administration:IP, 1 h before the testResult:Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.
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Synonyms3-((2-Methyl-13-thiazol-4-yl)ethyn-yl)pyridine hydrochloride | MTEP
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PathwayNeuroscience
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TargetGluR
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RecptormGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number1186195-60-7
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Formula Weight236.72
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Molecular FormulaC11H9ClN2S
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Purity>98% (HPLC)
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SolubilityH2O:20 mg/mL (84.49 mM; Need ultrasonic)
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SMILESCc1nc(C#Cc2cccnc2)cs1.Cl
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Chemical Name3-((2-Methyl-13-thiazol-4-yl)ethynyl)pyridine hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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SIB-1757
SIB-1757 is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM),SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?
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Ziyuglycoside II
Ziyuglycoside II has anticancer, and antitumor properties against gastric cancer and breast cancer cells, by cell cycle arrest and cell apoptosis.
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Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
